Josef Thingnes

• Thingnes, Josef (2014). Mathematics and Biological Process of Skin Pigmentation, In Bernard Querleux (ed.),  Computational Biophysics of the Skin.  Pan Stanford Publishing.  ISBN 978-981-4463-84-3.  Part 1, Chapter 3.  s 63 - 91
• Thingnes, Josef; Lavelle, Timothy J.; Gjuvsland, Arne Bjørke; Omholt, Stig W & Hovig, Eivind (2012). Towards a quantitative understanding of the MITF-PIAS3-STAT3 connection. BMC Systems Biology.  ISSN 1752-0509.  6 . doi: 10.1186/1752-0509-6-11
• Thingnes, Josef; Lavelle, Timothy J.; Hovig, Eivind & Omholt, Stig W (2012). Understanding the Melanocyte Distribution in Human Epidermis: An Agent-Based Computational Model Approach. PLoS ONE.  ISSN 1932-6203.  7(7) . doi: 10.1371/journal.pone.0040377
• Thingnes, Josef; Omholt, Stig W; Hovig, Eivind; Øyehaug, Leiv & Gjuvsland, Arne Bjørke (2012). Towards a quantitative understanding of melanocyte behaviour. Philosophiae Doctor (PhD) Thesis. 15.
• Thingnes, Josef; Øyehaug, Leiv; Hovig, Eivind & Omholt, Stig W. (2009). The mathematics of tanning. BMC Systems Biology.  ISSN 1752-0509.  3(0,166666667), s 14 Vis sammendrag

  Conclusion: Despite the paucity of experimental validation data the model is constrained enough to serve as a foundation for the establishment of a theoretical-experimental research programme aimed at elucidating the more fine-grained regulatory anatomy underlying the tanning response.

• Thingnes, Josef; Øyehaug, Leiv; Omholt, Stig W. & Hovig, Eivind (2008). The Mathematics of Tanning. Vis sammendrag

  Introduction We have made a mathematical conceptualisation of our present knowledge of the process of tanning. The model includes concepts as the production of melanin (melanogenesis) in melanocytes and the delivery of melanin through dendrites to nearby keratinocytes as well as the continuous movement of keratinocytes outwards through the layers of epidermis . When the skin is exposed to UV radiation, both keratinocytes and melanocytes produce different signal substances that bind to receptors on the melanocyte surface which in turn trigger both melanogenesis and dendrification.

• Thingnes, Josef; Øyehaug, Leiv; Hovig, Eivind & Omholt, Stig W. (2007). The mathematics of Tanning. Vis sammendrag

  Although cutaneous melanoma represents less than 5% of skin cancers, it has become a major public health problem in many countries due to a steady increase in its incidence. While melanoma is curable if diagnosed early and surgically excised, little progress has been made in medical treatment of metastatic melanoma because of its poor response to current therapies. Melanoma cells are derived from normal melanocytes, which are confined to the basal layer of the epidermis where they are interspersed among many more numerous keratinocytes. Substantial advances have been made recently in understanding the molecular pathogenesis of melanoma development and progression, but the potential of the identified pathways as therapeutic targets remains to be assessed. As a contribution to this understanding we will make mathematical models describing the molecular biology of the melanocytes and their surroundings. Mathematical modelling of biological systems has some advantages. The model itself is a clear presentation of the authors understanding of the problem. The work with the model will give insight and rice good questions. Simulations and analysis give falsifiable predictions

• Thingnes, Josef; Øyehaug, Leiv; Omholt, Stig W. & Hovig, Eivind (2007). The mathematics of tanning. Vis sammendrag

  Although cutaneous melanoma represents less than 5% of skin cancers, it has become a major public health problem in many countries due to a steady increase in its incidence. While melanoma is curable if diagnosed early and surgically excised, little progress has been made in medical treatment of metastatic melanoma because of its poor response to current therapies. Melanoma cells are derived from normal melanocytes, which are confined to the basal layer of the epidermis where they are interspersed among many more numerous keratinocytes. Substantial advances have been made recently in understanding the molecular pathogenesis of melanoma development and progression, but the potential of the identified pathways as therapeutic targets remains to be assessed. As a contribution to this understanding we will make mathematical models describing the molecular biology of the melanocytes and their surroundings. Mathematical modelling of biological systems has some advantages. The model itself is a clear presentation of the authors understanding of the problem. The work with the model will give insight and rice good questions. Simulations and analysis give falsifiable predictions

Se alle arbeider i Cristin

• Thingnes, Josef; Lavelle, Timothy J.; Gjuvsland, Arne Bjørke; Omholt, Stig W & Hovig, Eivind (2012). Towards a quantitative understanding of the MITF-PIAS3-STAT3 connection. BMC Systems Biology.  ISSN 1752-0509.  6 . doi: 10.1186/1752-0509-6-11
• Thingnes, Josef; Lavelle, Timothy J.; Hovig, Eivind & Omholt, Stig W (2012). Understanding the Melanocyte Distribution in Human Epidermis: An Agent-Based Computational Model Approach. PLoS ONE.  ISSN 1932-6203.  7(7) . doi: 10.1371/journal.pone.0040377
• Thingnes, Josef; Øyehaug, Leiv; Hovig, Eivind & Omholt, Stig W (2009). The mathematics of tanning. BMC Systems Biology.  ISSN 1752-0509.  3 . doi: 10.1186/1752-0509-3-60
• Thingnes, Josef; Øyehaug, Leiv; Hovig, Eivind & Omholt, Stig W. (2009). The mathematics of tanning. BMC Systems Biology.  ISSN 1752-0509.  3(0,166666667), s 14 Vis sammendrag

  Conclusion: Despite the paucity of experimental validation data the model is constrained enough to serve as a foundation for the establishment of a theoretical-experimental research programme aimed at elucidating the more fine-grained regulatory anatomy underlying the tanning response.

Se alle arbeider i Cristin

• Nagel, Ilka & Thingnes, Josef (2018). Digitalisering i Lærerutdanningene (DigiLU)- Presentasjon av prosjektet.
• Thingnes, Josef (2014). Mathematics and Biological Process of Skin Pigmentation, In Bernard Querleux (ed.),  Computational Biophysics of the Skin.  Pan Stanford Publishing.  ISBN 978-981-4463-84-3.  Part 1, Chapter 3.  s 63 - 91
• Thingnes, Josef; Omholt, Stig W; Hovig, Eivind; Øyehaug, Leiv & Gjuvsland, Arne Bjørke (2012). Towards a quantitative understanding of melanocyte behaviour. Philosophiae Doctor (PhD) Thesis. 15.
• Thingnes, Josef; Øyehaug, Leiv; Omholt, Stig W. & Hovig, Eivind (2008). The Mathematics of Tanning. Vis sammendrag

  Introduction We have made a mathematical conceptualisation of our present knowledge of the process of tanning. The model includes concepts as the production of melanin (melanogenesis) in melanocytes and the delivery of melanin through dendrites to nearby keratinocytes as well as the continuous movement of keratinocytes outwards through the layers of epidermis . When the skin is exposed to UV radiation, both keratinocytes and melanocytes produce different signal substances that bind to receptors on the melanocyte surface which in turn trigger both melanogenesis and dendrification.

• Thingnes, Josef; Øyehaug, Leiv; Hovig, Eivind & Omholt, Stig W. (2007). The mathematics of Tanning. Vis sammendrag

  Although cutaneous melanoma represents less than 5% of skin cancers, it has become a major public health problem in many countries due to a steady increase in its incidence. While melanoma is curable if diagnosed early and surgically excised, little progress has been made in medical treatment of metastatic melanoma because of its poor response to current therapies. Melanoma cells are derived from normal melanocytes, which are confined to the basal layer of the epidermis where they are interspersed among many more numerous keratinocytes. Substantial advances have been made recently in understanding the molecular pathogenesis of melanoma development and progression, but the potential of the identified pathways as therapeutic targets remains to be assessed. As a contribution to this understanding we will make mathematical models describing the molecular biology of the melanocytes and their surroundings. Mathematical modelling of biological systems has some advantages. The model itself is a clear presentation of the authors understanding of the problem. The work with the model will give insight and rice good questions. Simulations and analysis give falsifiable predictions

• Thingnes, Josef; Øyehaug, Leiv; Omholt, Stig W. & Hovig, Eivind (2007). The mathematics of tanning. Vis sammendrag

  Although cutaneous melanoma represents less than 5% of skin cancers, it has become a major public health problem in many countries due to a steady increase in its incidence. While melanoma is curable if diagnosed early and surgically excised, little progress has been made in medical treatment of metastatic melanoma because of its poor response to current therapies. Melanoma cells are derived from normal melanocytes, which are confined to the basal layer of the epidermis where they are interspersed among many more numerous keratinocytes. Substantial advances have been made recently in understanding the molecular pathogenesis of melanoma development and progression, but the potential of the identified pathways as therapeutic targets remains to be assessed. As a contribution to this understanding we will make mathematical models describing the molecular biology of the melanocytes and their surroundings. Mathematical modelling of biological systems has some advantages. The model itself is a clear presentation of the authors understanding of the problem. The work with the model will give insight and rice good questions. Simulations and analysis give falsifiable predictions

Se alle arbeider i Cristin